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The growth in pharmaceutical industry has paved ways to increased number of life saving drugs. The quality unit plays vital role in the timely release of pharmaceutical products with highest quality by using accurate and validated analytical methods. A chromatographic method was developed for the assay of Quetiapine-fumarate in drug formulations. It is an anti-psychotic drug used for treatment of depression disorders. The method includes Grace-C18 column and mobile phase composition of 0.1% ortho phosphoric acid and Acetonitrile (50:50, v/v). The validated method is accurate and can apply for routine quality control samples in pharmaceutical formulations.
The present research is chromatographic technique which the author has developed as an alternative to traditional methods. This method evaluates the purity and efficacy of the Quetiapine-fumarate tablets under different brand names. The method developed is highly specific, less cumbersome and can easily adaptable to quality control samples. The method under study is completely validated as per ICH quality guideline. The reported method is reproducible and accurate (99.5- 100%), reported time period of the method is less than 10 minutes. The kinetic behaviour and relative stability of the drug under different conditions of degradation study were evaluated.

Journal Name: journal fo chemistry , Volume Number: 2013 , Page Number: 578537 ,
Digital Object Identifier: 10.1038/nature.2014.14569


Bavirisetty Venkata Kiran Says

new rating On 2017-03-13 14:0

Bavirisetty Venkata Kiran Says

Good research work On 2017-05-11 11:4

Bavirisetty Venkata Kiran Says

timely project On 2017-06-30 18:1

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