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Analytical chemistry plays a primary role in control of medicines of highest quality. Development of highly accurate method is a first step in this direction. A rapid chromatographic method was developed for estimation of Abacavir sulphate in pharmaceutical formulations. Drug is used for the treatment of HIV infection in adults. The method involves Grace-C18 column and mobile phase composition of phosphate buffer and methanol (62:38, v/v). The wavelength of detection is 255 nm. The run time of method is 7 minutes. The validated method can apply for routine quality control samples in pharmaceutical formulations.
The present paper uses chromatographic technique as an alternative analytical tool to evaluate safety of pharmaceutical products. This method evaluates the purity and safety of the Abacavir sulphate tablets available in the market. The reported method is analytical friendly, affordable and can easily adaptable to quality control samples. The method developed is highly selective and free from interference of excepients. The reported method is reproducible and accurate (99.5- 100%), reported time period of the method is less than 10 minutes. The kinetic behaviour and relative stability of the Abacavir sulfate under different conditions of degradation study were evaluated.

Journal Name: International Journal of Pharmaceutical Sciences , Volume Number: 3(8) , Page Number: 2590 ,
Digital Object Identifier: https://dx.doi.org/10.6084/m9.figshare.1008040.v1

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Bavirisetty Venkata Kiran Says

Good On 2016-06-28 15:0

Bavirisetty Venkata Kiran Says

good project On 2017-03-06 18:2

Bavirisetty Venkata Kiran Says

new project On 2017-03-11 17:1

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