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The pharmaceutical industry is highly regulated market. Regulatory authorities place many quality control checks to ensure safe medicines reach patients. . Development of accurate and validated method is one such measure. A rapid chromatographic method was developed for the assay of Amolodipine and Metaprolol in drug formulations. The method includes ODS-C18 column and mobile phase composition of phosphate buffer and Methanol (70:30, v/v). The run time of method is 10 minutes. The validated method is accurate and can apply for routine quality control samples in pharmaceutical formulations.
The present paper focuses primarily on analytical procedures which the author has developed using chromatographic technique as a viable alternative to conventional methods. This method evaluates the purity and safety of different brands of Amalodipine and Metoprolol tablets available in the market. The method under study is successfully validated as per ICH quality guideline. The reported method is reproducible and accurate (99.5- 100%), reported time period of the method is less than 10 minutes. The reported method is analytical friendly, affordable and can easily adaptable to quality control laboratories of pharma industry and research institutes.

Journal Name: International Journal of Pharmacy and Pharmaceutical Sciences , Volume Number: 4(5) , Page Number: 401 ,
Digital Object Identifier: https://dx.doi.org/10.6084/m9.figshare.1008042.v1

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